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[18F]-FMH3

Development stage: Phase 1
Lead developer: Institute for Neurodegenerative Disorders
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[18F]-FMH3 is a diagnostic radiopharmaceutical developed as a highly specific positron emission tomography (PET) imaging biomarker for the histamine H3 receptor. It is used in research to visualize and quantify H3 receptor activity in the brain, particularly for studies related to neurodegenerative diseases such as Alzheimer's disease. The mechanism of action involves acting as a PET tracer that binds selectively to the histamine H3 receptor, allowing non-invasive imaging of its distribution and occupancy in vivo. Initial development was by the Institute for Neurodegenerative Disorders, with early clinical studies demonstrating promising brain uptake and specificity for H3 receptors in both human and non-human primates[1][2].

Other names: [18F]FMH3

Targets

HRH3 (Histamine Receptor H3)

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